MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite allergic rhinitis

Kortekaas Krohn, Inge; Callebaut, Ina; Aguiar Alpizar, Yeranddy; Steelant, Brecht; Van Gerven, Laura; Skov, Per Stahl; Kasran, Ahmad; Talavera Pérez, Karel; Wouters, Mira; Ceuppens, Jan; Seys, Sven; Hellings, Peter

doi:10.1111/all.13349

MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite allergic rhinitis

Author:

Kortekaas Krohn, Inge

Callebaut, Ina ; Aguiar Alpizar, Yeranddy ; Steelant, Brecht ; Van Gerven, Laura ; Skov, Per Stahl ; Kasran, Ahmad ; Talavera Pérez, Karel ; Wouters, Mira ; Ceuppens, Jan ; Seys, Sven ; Hellings, Peter

Keywords:

Science & Technology, Life Sciences & Biomedicine, Allergy, Immunology, allergic rhinitis, azelastine hydrochloride, fluticasone propionate, nasal hyperreactivity, substance P, ADVANCED DELIVERY-SYSTEM, CULTURED MAST-CELLS, AZELASTINE HYDROCHLORIDE, FLUTICASONE PROPIONATE, INTRANASAL FORMULATION, DOUBLE-BLIND, LONG-TERM, HISTAMINE, CAPSAICIN, NEURONS, Adult, Androstadienes, Animals, Anti-Allergic Agents, Double-Blind Method, Drug Combinations, Female, Humans, Male, Mast Cells, Mice, Mice, Inbred C57BL, Nasal Mucosa, Phthalazines, Pyroglyphidae, Rhinitis, Allergic, Perennial, Young Adult, 1107 Immunology, 3204 Immunology

Abstract:

Nasal hyperreactivity (NHR) is an important clinical feature of allergic rhinitis (AR). The efficacy of MP29-02 (azelastine hydrochloride (AZE) and fluticasone propionate (FP)) nasal spray on local inflammatory mediators and NHR in AR is unknown. We tested if MP29-02 decreases inflammatory mediators and NHR in AR and if this effect is due to restoration of nasal epithelial barrier function.