Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Psychiatry, gene-environment interaction, daily-life stressors, childhood trauma, psychosis, experience sampling method, CHILDHOOD TRAUMA, ENVIRONMENT INTERACTIONS, SCHIZOPHRENIA, FKBP5, SCHIZOTYPY, OXYTOCIN, RGS4, RISK, PSYCHOPATHOLOGY, POLYMORPHISM, Adult, Adult Survivors of Child Adverse Events, Cross-Sectional Studies, Ecological Momentary Assessment, Female, Gene-Environment Interaction, Humans, Individuality, Longitudinal Studies, Male, Polymorphism, Single Nucleotide, Psychotic Disorders, RGS Proteins, Stress, Psychological, Tacrolimus Binding Proteins, Young Adult, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, 32 Biomedical and clinical sciences, 42 Health sciences, 52 Psychology

Abstract:

The interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early-life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early-psychosis and non-clinical groups for these interactions.