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Keywords:

dmtu, hydrogen peroxide, fluorine-18, oxidative stress, free-radicals, metabolism, Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemical Research Methods, Chemistry, Medicinal, Chemistry, Analytical, Biochemistry & Molecular Biology, Pharmacology & Pharmacy, Chemistry, DMTU, FREE-RADICALS, METABOLISM, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, 3405 Organic chemistry

Abstract:

N-(2-[F-18]fluoroethyl)-N'-methylthiourea ([F-18]FEMTU), a fluorine-18 labelled derivative of the hydrogen peroxide scavenger dimethylthiourea (DMTU), has been synthesized by reaction of 2-[F-18]fluoroethylamine with methylisothiocyanate. 2-[F-18]Fluoroethylamine was obtained in modest radiochemical yields (39+/-6%, mean+/-sd, n=5, decay corrected) by nucleophilic substitution with [F-18]fluoride on N-[2(p-toluenesulfonyloxy)ethyl] phthalimide followed by deprotection with hydrazine and distillation.