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11th International Conference on Practical Applications of Computational Biology and Bioinformatics (PACBB), Date: 2017/06/21 - 2017/06/23, Location: PORTUGAL, Polytechn Porto, Porto

Publication date: 2017-01-01
Volume: 616 Pages: 248 - 256
ISSN: 978-3-319-60815-0
Publisher: Springer Verlag

11TH INTERNATIONAL CONFERENCE ON PRACTICAL APPLICATIONS OF COMPUTATIONAL BIOLOGY & BIOINFORMATICS

Author:

Tavares, Ana Helena
Raymaekers, Jakob ; Rousseeuw, Peter J ; Silva, Raquel M ; Bastos, Carlos AC ; Pinho, Armando ; Brito, Paula ; Afreixo, Vera

Keywords:

Science & Technology, Life Sciences & Biomedicine, Mathematical & Computational Biology, Inter-word distance, Reversed complements, Dissimilarity measure, Human genome, C16/15/068#53326575

Abstract:

© Springer International Publishing AG 2017. In this work we explore the dissimilarity between symmetric word pairs, by comparing the inter-word distance distribution of a word to that of its reversed complement. We propose a new measure of dissimilarity between such distributions. Since symmetric pairs with different patterns could point to evolutionary features, we search for the pairs with the most dissimilar behaviour. We focus our study on the complete human genome and its repeat-masked version.