Author:

Keywords:

Adolescent, Area Under Curve, Child, Dose-Response Relationship, Drug, Double-Blind Method, Follow-Up Studies, Glucocorticoids, Heart Rate, Humans, International Cooperation, Male, Muscular Dystrophy, Duchenne, Quality of Life, Respiratory Function Tests, Tadalafil, Treatment Outcome, Vasodilator Agents, Ventricular Function, Left, Walking, Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, FUNCTIONAL MUSCLE ISCHEMIA, MDX MOUSE MODEL, OXIDE SYNTHASE TRANSGENE, NITRIC-OXIDE, SKELETAL-MUSCLE, SILDENAFIL, NNOS, PERFORMANCE, SARCOLEMMA, VASOCONSTRICTION, Tadalafil DMD Study Group, 1103 Clinical Sciences, 1109 Neurosciences, 1702 Cognitive Sciences, Neurology & Neurosurgery, 3202 Clinical sciences, 3209 Neurosciences

Abstract:

To conduct a randomized trial to test the primary hypothesis that once-daily tadalafil, administered orally for 48 weeks, lessens the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD).