Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts

Sindberg, Gregory M; Lindborg, Beth A; Wang, Qi; Clarkson, Christina; Graham, Melanie; Donahue, Robert; Hering, Bernhard J; Verfaillie, Catherine; Bansal-Pakala, Pratima; O'Brien, Timothy D

doi:10.1111/jmp.12122

Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts

Author:

Sindberg, Gregory M

Lindborg, Beth A ; Wang, Qi ; Clarkson, Christina ; Graham, Melanie ; Donahue, Robert ; Hering, Bernhard J ; Verfaillie, Catherine ; Bansal-Pakala, Pratima ; O'Brien, Timothy D

Keywords:

Science & Technology, Life Sciences & Biomedicine, Veterinary Sciences, Zoology, cellular therapy, immunophenotype, T-cell suppression, STEM-CELLS, STROMAL CELLS, IMMUNOSUPPRESSION, ACTIVATION, STRATEGY, DISEASE, CULTURE, Adult Stem Cells, Animals, Bone Marrow Cells, Cell Line, Female, Fibroblasts, Immunosuppression Therapy, Macaca mulatta, Male, Mesenchymal Stem Cells, Phenotype, Skin, 0608 Zoology, 0707 Veterinary Sciences, Virology, 3009 Veterinary sciences

Abstract:

Potent immunomodulatory effects have been reported for mesenchymal stem/stromal cells (MSCs), multipotent adult progenitor cells (MAPCs), and fibroblasts. However, side-by-side comparisons of these cells specifically regarding immunophenotype, gene expression, and suppression of proliferation of CD4(+) and CD8(+) lymphocyte populations have not been reported.