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PLoS Medicine

Publication date: 2016-08-01
Volume: 13
Publisher: Public Library of Science

Author:

Guo, Yansong
Warren Andersen, Shaneda ; Shu, Xiao-Ou ; Michailidou, Kyriaki ; Bolla, Manjeet K ; Wang, Qin ; Garcia-Closas, Montserrat ; Milne, Roger L ; Schmidt, Marjanka K ; Chang-Claude, Jenny ; Dunning, Allison ; Bojesen, Stig E ; Ahsan, Habibul ; Aittomäki, Kristiina ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arndt, Volker ; Beckmann, Matthias W ; Beeghly-Fadiel, Alicia ; Benitez, Javier ; Bogdanova, Natalia V ; Bonanni, Bernardo ; Børresen-Dale, Anne-Lise ; Brand, Judith ; Brauch, Hiltrud ; Brenner, Hermann ; Brüning, Thomas ; Burwinkel, Barbara ; Casey, Graham ; Chenevix-Trench, Georgia ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Czene, Kamila ; Devilee, Peter ; Dörk, Thilo ; Dumont, Martine ; Fasching, Peter A ; Figueroa, Jonine ; Flesch-Janys, Dieter ; Fletcher, Olivia ; Flyger, Henrik ; Fostira, Florentia ; Gammon, Marilie ; Giles, Graham G ; Guénel, Pascal ; Haiman, Christopher A ; Hamann, Ute ; Hooning, Maartje J ; Hopper, John L ; Jakubowska, Anna ; Jasmine, Farzana ; Jenkins, Mark ; John, Esther M ; Johnson, Nichola ; Jones, Michael E ; Kabisch, Maria ; Kibriya, Muhammad ; Knight, Julia A ; Koppert, Linetta B ; Kosma, Veli-Matti ; Kristensen, Vessela ; Le Marchand, Loic ; Lee, Eunjung ; Li, Jingmei ; Lindblom, Annika ; Luben, Robert ; Lubinski, Jan ; Malone, Kathi E ; Mannermaa, Arto ; Margolin, Sara ; Marme, Frederik ; McLean, Catriona ; Meijers-Heijboer, Hanne ; Meindl, Alfons ; Neuhausen, Susan L ; Nevanlinna, Heli ; Neven, Patrick ; Olson, Janet E ; Perez, Jose IA ; Perkins, Barbara ; Peterlongo, Paolo ; Phillips, Kelly-Anne ; Pylkäs, Katri ; Rudolph, Anja ; Santella, Regina ; Sawyer, Elinor J ; Schmutzler, Rita K ; Seynaeve, Caroline ; Shah, Mitul ; Shrubsole, Martha J ; Southey, Melissa C ; Swerdlow, Anthony J ; Toland, Amanda E ; Tomlinson, Ian ; Torres, Diana ; Truong, Thérèse ; Ursin, Giske ; Van Der Luijt, Rob B ; Verhoef, Senno ; Whittemore, Alice S ; Winqvist, Robert ; Zhao, Hui ; Zhao, Shilin ; Hall, Per ; Simard, Jacques ; Kraft, Peter ; Pharoah, Paul ; Hunter, David ; Easton, Douglas F ; Zheng, Wei

Keywords:

Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, GENOME-WIDE ASSOCIATION, HORMONE-RECEPTOR STATUS, GENOTYPE IMPUTATION, PROSPECTIVE COHORT, FAT DISTRIBUTION, RELATIVE WEIGHT, OBESITY, LOCI, SIZE, METAANALYSIS, Body Mass Index, Breast Neoplasms, Female, Genetic Predisposition to Disease, Humans, Mendelian Randomization Analysis, Menopause, Middle Aged, Models, Statistical, Polymorphism, Single Nucleotide, Risk Factors, White People, 11 Medical and Health Sciences, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.