Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Zhao, Zhiguo; Wen, Wanqing; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Zhang, Ben; Long, Jirong; Shu, Xiao-Ou; Schmidt, Marjanka K; Milne, Roger L; García-Closas, Montserrat; Chang-Claude, Jenny; Lindstrom, Sara; Bojesen, Stig E; Ahsan, Habibul; Aittomäki, Kristiina; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Beckmann, Matthias W; Beeghly-Fadiel, Alicia; Benitez, Javier; Blomqvist, Carl; Bogdanova, Natalia V; Børresen-Dale, Anne-Lise; Brand, Judith; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Cai, Qiuyin; Casey, Graham; Chenevix-Trench, Georgia; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dörk, Thilo; Dumont, Martine; Fasching, Peter A; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Flyger, Henrik; Fostira, Florentia; Gammon, Marilie; Giles, Graham G; Guénel, Pascal; Haiman, Christopher A; Hamann, Ute; Harrington, Patricia; Hartman, Mikael; Hooning, Maartje J; Hopper, John L; Jakubowska, Anna; Jasmine, Farzana; John, Esther M; Johnson, Nichola; Kabisch, Maria; Khan, Sofia; Kibriya, Muhammad; Knight, Julia A; Kosma, Veli-Matti; Kriege, Mieke; Kristensen, Vessela; Le Marchand, Loic; Lee, Eunjung; Li, Jingmei; Lindblom, Annika; Lophatananon, Artitaya; Luben, Robert; Lubinski, Jan; Malone, Kathleen E; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Frederik; McLean, Catriona; Meijers-Heijboer, Hanne; Meindl, Alfons; Miao, Hui; Muir, Kenneth; Neuhausen, Susan L; Nevanlinna, Heli; Neven, Patrick; Olson, Janet E; Perkins, Barbara; Peterlongo, Paolo; Phillips, Kelly-Anne; Pylkäs, Katri; Rudolph, Anja; Santella, Regina; Sawyer, Elinor J; Schmutzler, Rita K; Schoemaker, Minouk; Shah, Mitul; Shrubsole, Martha; Southey, Melissa C; Swerdlow, Anthony J; Toland, Amanda E; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Ursin, Giske; Van Der Luijt, Rob B; Verhoef, Senno; Wang-Gohrke, Shan; Whittemore, Alice S; Winqvist, Robert; Pilar Zamora, M; Zhao, Hui; Dunning, Alison M; Simard, Jacques; Hall, Per; Kraft, Peter; Pharoah, Paul; Hunter, David; Easton, Douglas F; Zheng, Wei

doi:10.1007/s10552-016-0741-6

Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Author:

Zhao, Zhiguo

Wen, Wanqing ; Michailidou, Kyriaki ; Bolla, Manjeet K ; Wang, Qin ; Zhang, Ben ; Long, Jirong ; Shu, Xiao-Ou ; Schmidt, Marjanka K ; Milne, Roger L ; García-Closas, Montserrat ; Chang-Claude, Jenny ; Lindstrom, Sara ; Bojesen, Stig E ; Ahsan, Habibul ; Aittomäki, Kristiina ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arndt, Volker ; Beckmann, Matthias W ; Beeghly-Fadiel, Alicia ; Benitez, Javier ; Blomqvist, Carl ; Bogdanova, Natalia V ; Børresen-Dale, Anne-Lise ; Brand, Judith ; Brauch, Hiltrud ; Brenner, Hermann ; Burwinkel, Barbara ; Cai, Qiuyin ; Casey, Graham ; Chenevix-Trench, Georgia ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Czene, Kamila ; Dörk, Thilo ; Dumont, Martine ; Fasching, Peter A ; Figueroa, Jonine ; Flesch-Janys, Dieter ; Fletcher, Olivia ; Flyger, Henrik ; Fostira, Florentia ; Gammon, Marilie ; Giles, Graham G ; Guénel, Pascal ; Haiman, Christopher A ; Hamann, Ute ; Harrington, Patricia ; Hartman, Mikael ; Hooning, Maartje J ; Hopper, John L ; Jakubowska, Anna ; Jasmine, Farzana ; John, Esther M ; Johnson, Nichola ; Kabisch, Maria ; Khan, Sofia ; Kibriya, Muhammad ; Knight, Julia A ; Kosma, Veli-Matti ; Kriege, Mieke ; Kristensen, Vessela ; Le Marchand, Loic ; Lee, Eunjung ; Li, Jingmei ; Lindblom, Annika ; Lophatananon, Artitaya ; Luben, Robert ; Lubinski, Jan ; Malone, Kathleen E ; Mannermaa, Arto ; Manoukian, Siranoush ; Margolin, Sara ; Marme, Frederik ; McLean, Catriona ; Meijers-Heijboer, Hanne ; Meindl, Alfons ; Miao, Hui ; Muir, Kenneth ; Neuhausen, Susan L ; Nevanlinna, Heli ; Neven, Patrick ; Olson, Janet E ; Perkins, Barbara ; Peterlongo, Paolo ; Phillips, Kelly-Anne ; Pylkäs, Katri ; Rudolph, Anja ; Santella, Regina ; Sawyer, Elinor J ; Schmutzler, Rita K ; Schoemaker, Minouk ; Shah, Mitul ; Shrubsole, Martha ; Southey, Melissa C ; Swerdlow, Anthony J ; Toland, Amanda E ; Tomlinson, Ian ; Torres, Diana ; Truong, Thérèse ; Ursin, Giske ; Van Der Luijt, Rob B ; Verhoef, Senno ; Wang-Gohrke, Shan ; Whittemore, Alice S ; Winqvist, Robert ; Pilar Zamora, M ; Zhao, Hui ; Dunning, Alison M ; Simard, Jacques ; Hall, Per ; Kraft, Peter ; Pharoah, Paul ; Hunter, David ; Easton, Douglas F ; Zheng, Wei

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, Public, Environmental & Occupational Health, Type 2 diabetes, Genetic susceptibility, GWAS, Breast cancer, Epidemiology, GENOME-WIDE ASSOCIATION, MULTIETHNIC COHORT, MELLITUS, LOCI, OBESITY, Breast Neoplasms, Case-Control Studies, Diabetes Mellitus, Type 2, Ethnicity, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Risk Factors, White People, 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services, 3211 Oncology and carcinogenesis, 4202 Epidemiology

Abstract:

Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.