PLoS One
Author:
Keywords:
Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Case-Control Studies, Humans, Interferon Regulatory Factors, Multiple Sclerosis, Polymorphism, Single Nucleotide, Receptors, Tumor Necrosis Factor, Type I, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, GENOME-WIDE ASSOCIATION, PERIODIC-SYNDROME, EXPRESSION, APOPTOSIS, MUTATION, REVEALS, DOMAIN, ROLES, International Multiple Sclerosis Genetics Consortium, General Science & Technology
Abstract:
In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). To refine our understanding of these associations we sought to replicate these findings in a large more extensive independent sample set of 11 populations of European origin.