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PLoS One

Publication date: 2011-04-01
Publisher: Public Library of Sciene

Author:

The International Multiple Sclerosis Genetics Consortium,
Leppä, Virpi ; Suraka, Ida ; Tienari, Pentti ; Elovaara, Irina ; Compston, Alastair ; Sawcer, Stephen ; Robertson, Neil ; De Jager, Philip ; Aubin, Cristin ; Hafler, David ; Bang Oturai, Annette ; Bach Sondergaard, Helle ; Sellebjerg, Finn ; SoelbergSorensen, Per ; Hemmer, Bernhard ; Cepok, Sabine ; Winkelmann, Juliane ; Wichmann, Heinz-Eric ; Comabella, Manuel ; Bustamante, Marta ; Montalban, Xavier ; Olsson, Tomas ; Kockum, Ingrid ; Hillert, Jan ; Alfredsson, Lars ; Goris, An ; Dubois, Bénédicte ; Mero, Inger-Lise ; Smestad, Cathrine ; Celius, Elisabeth ; Harbo, Hanne ; D'Alfonso, Sandra ; Bergamaschi, Laura ; Maurizio, Leone ; Ristori, Giovanni ; Kappos, Ludwig ; Hauser, Stephen ; Cournu-Rebeix, Isabelle ; Fontaine, Bertrand ; Boonen, Steven ; Polman, Chris ; Palotie, Arnoo ; Peltonen, Leena ; Saarela, Janna

Keywords:

Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Case-Control Studies, Humans, Interferon Regulatory Factors, Multiple Sclerosis, Polymorphism, Single Nucleotide, Receptors, Tumor Necrosis Factor, Type I, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, GENOME-WIDE ASSOCIATION, PERIODIC-SYNDROME, EXPRESSION, APOPTOSIS, MUTATION, REVEALS, DOMAIN, ROLES, International Multiple Sclerosis Genetics Consortium, General Science & Technology

Abstract:

In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). To refine our understanding of these associations we sought to replicate these findings in a large more extensive independent sample set of 11 populations of European origin.