Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, TRANSPARENT OIL-WATER GEL, INDOMETHACIN, SOLUBILIZATION, DRUG STABILITY, KINETICS, SURFACTANTS, HYDROLYSIS, DEGRADATION, SYSTEM, 1115 Pharmacology and Pharmaceutical Sciences, 3214 Pharmacology and pharmaceutical sciences

Abstract:

Drug incorporation and stability in a model transparent oil-water gel (TOW gel) were investigated using indomethacin as the active component. Solubility measurements at pH 2.0 show that indomethacin is solubilized in the mixed surfactant aggregates present in the TOW gel. Solubilization tests in aqueous surfactant solutions at pH 5.6 and 7.8 prove that not only indomethacin, but also its sodium salt, dissolved and/or as the ion pair, is solubilized. The Solubilization reduces the acid and base catalysed indomethacin hydrolysis occuring in aqueous solutions. After 300 days of storage, at room temperature and protected from light, no indomethacin degradation is observed in the TOW gels with pH 9, the water phase at 5.6 and 7.6. © 1993.