Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Rehabilitation, Sport Sciences, Biomechanics, Botulinum toxins, Cerebral palsy, Electromyography, Muscle spasticity, MODIFIED ASHWORTH SCALE, INTERRATER RELIABILITY, CONTROLLED TRIAL, TARDIEU SCALE, LOWER-LIMB, MUSCLE, HEMIPLEGIA, PARAMETERS, INJECTIONS, EFFICACY, LIMB, CATCH, Adolescent, Botulinum Toxins, Type A, Cerebral Palsy, Child, Child, Preschool, Disability Evaluation, Female, Humans, Leg, Male, Muscle Spasticity, Neuromuscular Agents, Physical Therapy Modalities, Prospective Studies, ROC Curve, 1103 Clinical Sciences, 1106 Human Movement and Sports Sciences, 1117 Public Health and Health Services, 3202 Clinical sciences, 4201 Allied health and rehabilitation science, 4207 Sports science and exercise

Abstract:

OBJECTIVE: To compare responsiveness and predictive ability of clinical and instrumented spasticity assessments after botulinum toxin type A (BTX) treatment combined with casting in the medial hamstrings (MEHs) in children with spastic cerebral palsy (CP). DESIGN: Prospective cohort study. SETTING: Hospital. PARTICIPANTS: Consecutive sample of children (N=31; 40 MEH muscles) with CP requiring BTX injections. INTERVENTION: Clinical and instrumented spasticity assessments before and on average ± SD 53±14 days after BTX. MAIN OUTCOME MEASURES: Clinical spasticity scales included the Modified Ashworth Scale and the Modified Tardieu Scale. The instrumented spasticity assessment integrated biomechanical (position and torque) and electrophysiological (surface electromyography) signals during manually performed low- and high-velocity passive stretches of the MEHs. Signals were compared between both stretch velocities and were examined pre- and post-BTX. Responsiveness of clinical and instrumented assessments was compared by percentage exact agreement. Prediction ability was assessed with a logistic regression and the area under the receiver operating characteristic (ROC) curves of the baseline parameters of responders versus nonresponders. RESULTS: Both clinical and instrumented parameters improved post-BTX (P≤.005); however, they showed a low percentage exact agreement. The baseline Modified Tardieu Scale was the only clinical scale predictive for response (area under the ROC curve=0.7). For the instrumented assessment, baseline values of root mean square (RMS) electromyography and torque were better predictors for a positive response (area under the ROC curve=.82). Baseline RMS electromyography remained an important predictor in the logistic regression. CONCLUSIONS: The instrumented spasticity assessment showed higher responsiveness than the clinical scales. The amount of RMS electromyography is considered a promising parameter to predict treatment response.