Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, Genetics & Heredity, CYTOGENETIC FINDINGS, CHROMOSOME, TRANSLOCATION, XP11.2, Adolescent, Adult, Chromosome Aberrations, Chromosomes, Human, Pair 18, Chromosomes, Human, X, Cytogenetic Analysis, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Multiple Primary, Organ Specificity, Sarcoma, Synovial, Translocation, Genetic, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3105 Genetics, 3211 Oncology and carcinogenesis

Abstract:

Cytogenetic analysis was performed of six monophasic synovial sarcomas (four primary, two recurrent tumors) and one recurrent poorly differentiated synovial sarcoma with complex tumor-specific t(X;18). In the complex translocations, besides chromosomes X and 18, the following chromosomes were involved: 1, 3, 5, 15, and 17. In all, taking these results together with findings of 20 previously published synovial sarcoma tumors with complex t(X;18), 13 different chromosomes were involved. Chromosomes 15 (22% of tumors) and 1, 5, and 12 (approximately 11% each) were the most frequently involved in complex translocation, but with different breakpoints. In our laboratories, complex tumor-specific t(X;18) ranged from 2.5% to 11.7% (average 6.5%) of synovial sarcoma karyotypes.