Author:

Keywords:

neoplasm circulating cells [c23.550.727.650.645], real-time rt-pcr, quantitative rt-pcr, reverse transcription polymerase chain reaction [e05.393.620.500.725], colorectal neoplasms [c04.588.274.476.411.307], polymerase-chain-reaction, guanylyl cyclase-c, cancer stem-cells, cytokeratin-20 messenger-rna, reverse transcription-pcr, real-time pcr, clinical-significance, venous-blood, molecular-detection, breast-cancer, Science & Technology, Life Sciences & Biomedicine, Surgery, neoplasm circulating cells [C23.550.727.650.645], real-time RT-PCR, quantitative RT-PCR, reverse transcription polymerase chain reaction [E05.393.620.500.725], colorectal neoplasms [C04.588.274.476.411.307], POLYMERASE-CHAIN-REACTION, GUANYLYL CYCLASE-C, CANCER STEM-CELLS, CYTOKERATIN-20 MESSENGER-RNA, REVERSE TRANSCRIPTION-PCR, REAL-TIME PCR, CLINICAL-SIGNIFICANCE, VENOUS-BLOOD, MOLECULAR-DETECTION, BREAST-CANCER, Adenocarcinoma, Blood Specimen Collection, Colorectal Neoplasms, Humans, Immunomagnetic Separation, Neoplasm Metastasis, Predictive Value of Tests, Reverse Transcriptase Polymerase Chain Reaction, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Background. Twenty percent to 40% of patients with node-negative colorectal cancer die of metastatic disease. Detection of cancer cell dissemination has been proposed as a tool to select patients at highest risk for recurrence. In this review, we summarize the evidence for detection with quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) assays of circulating tumor cells (CTCs) in peripheral blood of colorectal cancer patients.