Author:

Keywords:

Science & Technology, Social Sciences, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, Social Sciences, Biomedical, Biomedical Social Sciences, Attitudes, Ethics, Preimplantation genetic testing, Polygenic risk scores, Reproductive genetics, Qualitative methods, Europe, North-America, DIAGNOSIS, CHILDREN, Pregnancy, Female, Child, Humans, Preimplantation Diagnosis, Genetic Risk Score, Genetic Testing, Health Personnel, Delivery of Health Care, MATER - 813707;info:eu-repo/grantAgreement/EC/H2020/813707, 11 Medical and Health Sciences, 14 Economics, 16 Studies in Human Society, Public Health, 38 Economics, 42 Health sciences, 44 Human society

Abstract:

The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-P) has been met with many concerns. To get more insights into the perspectives of relevant stakeholders on the socio-ethical aspects of PGT-P, an interview study with 31 healthcare professionals involved in reproductive medicine and genetics in Europe and North-America was performed. Healthcare professionals in our study were concerned that PGT-P was going too far in terms of selection, with regards to both medical conditions and non-medical traits. Healthcare professionals were worried about the ethical 'slippery slope' of PGT-P, the increasing medicalization of reproductive health, the commercial context of PGT-P, and potential stigmatization and discrimination. There were also concerns that the availability and the 'technological imperative' of PGT-P could lead to pressure and a sense of responsibility for parents to use PGT-P. Additionally, it could cause new anxieties about the child's health before the child has even been born. Since PGT-P provides polygenic risk scores before birth, the autonomy of the child has to be considered. These socio-ethical concerns heighten existing debates regarding reproductive genetic technologies and show that the specifics of PGT-P make this screening option especially ethically controversial.