Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Atrial fibrillation, Catheter ablation, Ethnicity, Race, Sex differences, Supraventricular tachycardia, Ventricular arrhythmia, GENDER-RELATED DIFFERENCES, VENTRICULAR-TACHYCARDIA ABLATION, STRUCTURAL HEART-DISEASE, LONG-TERM SUCCESS, ATRIAL-FIBRILLATION, ISCHEMIC CARDIOMYOPATHY, SUBSTRATE ABLATION, CLINICAL-TRIALS, UNITED-STATES, OUTCOMES

Abstract:

Sex and racial disparities in the presentation, diagnosis, and management of cardiac arrhythmias are recognized. Sex-specific differences in electrophysiological parameters are well known and are predominantly related to differences in ion channel expression and the influence of sex hormones. However, the relationship between hormonal or racial influence and arrhythmia mechanisms, presentation, and management needs to be better defined. Women and racial and ethnic groups are less likely to undergo catheter ablation procedures for treatment of cardiac arrhythmias. Underrepresentation of women and racial/ethnic groups in clinical trials has resulted in significant knowledge gaps. Whether sex and racial disparities in arrhythmia management reflect barriers in access to care, physician bias, patient values, and preferences or other factors requires further study.