Author:

Keywords:

C16/17/010#54271312, G0F7519N#54971556, 11A4220N|11A4222N#55341643

Abstract:

During several medical conditions such as trauma, surgery or transplantation, the blood flow to an organ can be reduced or even completely interrupted. The resulting lack of oxygen stresses the organ. Subsequent restoration of the blood flow causes inflammation and leads to further damage. Some damage is an inevitable consequence of kidney transplantation. However, the kidney injury can result in severe consequences for the patient, who receives the kidney. The organ may not function well, leading to mortality, morbidity, the need for prolonged stay in the hospital and/or dialysis. An inflammatory response of the body, characterized by an influx of white blood cells and especially neutrophils (a certain type of white blood cells), plays an important role in this process. In this project, we will inhibit the recruitment of white blood cells to the organ by using several synthetic peptides. First, various peptides will be synthesized, then the efficiency and potential toxicity will be evaluated and optimized. The best peptides will subsequently be selected and tested in a mouse model of the disease in order to investigate their anti-inflammatory activity.