Author:

Keywords:

ADDUCTION MOMENT, ANGLE, Biology, BIOMECHANICS, CONTACT FORCE, dynamic simulations, knee adduction moment, knee flexion moment, knee osteoarthritis, Life Sciences & Biomedicine, Life Sciences & Biomedicine - Other Topics, LOADS, medial contact force, Microbiology, musculoskeletal modeling, OpenSim Moco, optimization, participant-specific modeling, PREDICT, PREVALENCE, Science & Technology, SIMULATIONS, WALKING, 3101 Biochemistry and cell biology, 3104 Evolutionary biology, 4601 Applied computing

Abstract:

A high contact force between the medial femoral condyle and the tibial plateau is the primary cause of medial compartment knee osteoarthritis (OA). A high medial contact force (MCF) during gait has been shown to be correlated to both the knee adduction moment (KAM) and knee flexion/extension moment (KFM). In this study, we used OpenSim Moco to find gait kinematics that reduced the peaks of the KAM, without increasing the peaks of the KFM, which could potentially reduce the MCF and, hence, the progression of knee OA. We used gait data from four knee OA participants. Our simulations decreased both peaks of the KAM without increasing either peak of the KFM. We found that increasing the step width was the primary mechanism, followed by simulations of all participants to reduce the frontal plane lever arm of the ground reaction force vector about the knee, in turn reducing the KAM. Importantly, each participant simulation followed different patterns of kinematic changes to achieve this reduction, which highlighted the need for participant-specific gait modifications. Moreover, we were able to simulate emerging gait patterns within 15 min, enhancing the relevance and potential for the application of developed methods in clinical settings.