Journal of Organic Chemistry
Publication date:
2021-03-05
Volume:
86
Pages:
4346 -
4354
Publisher:
American Chemical Society
Author:
Veettil, Santhini Pulikkal
Parambil, Shandev Pookkandam ; Van Hoof, Max ; Dehaen, Wim
Keywords:
Science & Technology, Physical Sciences, Chemistry, Organic, Chemistry, C14/19/078#55221580, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, Organic Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry
Abstract:
A multicomponent reaction of triazoloketones, primary amines, and 4-nitrophenyl azide was developed for the synthesis of hitherto unknown angularly fused/linear bitriazoles. The two-stage mechanism was well proven by the isolation of the intermediate. This sequential reaction consists of Cornforth rearrangement and triazolization, which has also been demonstrated in a one-pot manner.