Author:

Keywords:

Science & Technology, Physical Sciences, Chemistry, Applied, Chemistry, Organic, Polymer Science, Chemistry, Polyvinyl alcohol, N?Succinyl chitosan, Hydrogels, Antibacterial property, Freezing, thawing, Wound dressing, CROSS-LINKED HYDROGELS, DRUG-DELIVERY SYSTEM, POLY(VINYL ALCOHOL), GRAPHENE OXIDE, BIOLOGICAL-ACTIVITY, CHITOSAN, MEMBRANES, ACID, REMOVAL, SILVER, Freezing/thawing, N–Succinyl chitosan, Anti-Bacterial Agents, Bandages, Hydrocolloid, Cell Survival, Chitosan, Drug Liberation, HaCaT Cells, Humans, Lincomycin, Materials Testing, Microbial Sensitivity Tests, Polyvinyl Alcohol, Wound Healing, 0303 Macromolecular and Materials Chemistry, 0305 Organic Chemistry, 0908 Food Sciences, Polymers, 3006 Food sciences, 3101 Biochemistry and cell biology, 4004 Chemical engineering

Abstract:

Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues. Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA. The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated. The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water. The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus. Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels. In summary, this PVA/NSCS/lincomycin hydrogel showed promising potential for wound dressing.