Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, Health Care Sciences & Services, Rehabilitation, Prospective cohort study, Breast cancer surgery, Persistent pain, Risk factors, Biopsychosocial model, PERSISTENT POSTSURGICAL PAIN, QUALITY-OF-LIFE, CENTRAL SENSITIZATION, SOCIAL SUPPORT, WOMEN, VALIDATION, PREDICTORS, SURVIVORS, IMPACT, Breast Neoplasms, Disability Evaluation, Female, Humans, Pain, Pain, Postoperative, Prospective Studies, Quality of Life, Risk Factors, Surveys and Questionnaires, 12R1719N#54765167, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, Oncology & Carcinogenesis, 32 Biomedical and clinical sciences, 42 Health sciences, 52 Psychology

Abstract:

PURPOSE: Knowledge regarding risk factors for pain in the long term after surgery for breast cancer may be of great value in preventing this prevalent and debilitating side effect. Despite the biopsychosocial nature of pain, the predictive value of both pre- and postoperative biopsychosocial functioning for long-term pain intensity and pain-related disability has not yet been studied. METHODS: One hundred sixty-six women planned for unilateral breast cancer surgery were included in this prospective cohort study. Pre- and postoperative outcomes related to pain, psychosocial, and somatosensory functioning (questionnaires and quantitative sensory testing) were evaluated as risk factors for pain intensity (visual analog scale) and pain-related disability (pain disability index) 1 year after surgery for breast cancer. Both bivariable and stepwise linear regression analyses were performed. RESULTS: The most consistent biopsychosocial risk factors were symptoms related to altered central somatosensory functioning (central sensitization inventory), psychological symptoms, and social support (psychological symptoms and support subscale of McGill Quality of Life Questionnaire). Results also showed that a pre- and postoperative disturbed functioning of the somatosensory nervous system in the surgical area could provide additional information regarding pain intensity or pain-related disability in the long term after surgery for breast cancer. CONCLUSION: This study revealed several biopsychosocial characteristics that might be used to identify women more vulnerable to have pain and pain-related disability in the long term after surgery for breast cancer, allowing for more effective pain management and prevention.