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Title: The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element
Authors: Haelens, Anna ×
Verrijdt, Guy
Schoenmakers, Erik
Alen, P
Peeters, Benjamin
Rombauts, Wilfried
Claessens, Frank #
Issue Date: Jul-1999
Series Title: Molecular and cellular endocrinology. vol:153 issue:1-2 pages:91-102
Abstract: Secretory component (SC) plays a key role in the transport of IgA and IgM to the lumina of many glands. The gene is constitutively expressed, but can be modulated by hormonal and immunological stimuli. Recently, the promoter and the first exon of the human sc gene have been cloned. The first exon contains a putative androgen/glucocorticoid response element (ARE/GRE) and an Interferon Regulatory Factor Element (IRF-E). Here we show that the ARE/GRE can bind the DNA-binding domain (DBD) of both the androgen (AR) and glucocorticoid receptor (GR) with a preference for the AR-DBD. In transient transfection experiments, this element confers higher responsiveness to androgens than to glucocorticoids. The IRF-E can function as an IRF-2, but surprisingly not as an IRF-I responsive element. We postulate that these two regulatory elements play a key role in the complex regulation of the sc gene in vivo.
ISSN: 0303-7207
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Laboratory of Molecular Endocrinology
× corresponding author
# (joint) last author

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