One of the leading models on antecedents of subjective well-being and stress at work is the job Demand-Control-Support model. Be it to a lesser extent, this model has also been applied to the study of burnout. In this study we tried to extend this model with work-home interference, which can be considered an additional stressor. 2075 Belgian nurses divided over 14 hospitals participated in this study. The results of hierarchical regression analyses showed a strong additional effect of work-home interference on each of the three dimensions of burnout, after controlling for the dimensions of the job Demand-Control-Support model. However, mediational analyses showed that the effect of work-home interference on depersonalization was partly mediated by emotional exhaustion and that the effect on personal accomplishment was partly mediated by emotional exhaustion and depersonalization.