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Title: Rat prostatic binding protein: the complete sequence of the C2 gene and its flanking regions
Authors: Delaey, Bernard ×
Dirckx, Luc
Decourt, Jean-Luc
Claessens, Frank
Peeters, Benjamin
Rombauts, Wilfried #
Issue Date: Feb-1987
Series Title: Nucleic acids research. vol:15 issue:4 pages:1627-41
Abstract: The complete sequence (2879 bp) of the androgen-controlled rat prostatic binding protein C2 gene and 1023 bp of the 5'- and 2127 bp of the 3'-flanking regions have been determined. The gene contains three exons (93, 203 and 147 bp) and two introns (1630 and 806 bp). It is flanked by two homopurine-homopyrimidine stretches of 55 and 131 nucleotides respectively, located at positions -405 and 4151. These sequences are remarkably sensitive towards S1-nuclease, indicating an altered DNA conformation under superhelical stress. Several palindromes and dyad structures are observed in the 5'-upstream region of the gene and at position -457, and 80% homology to the consensus sequence of a glucocorticoid receptor binding site is found.
ISSN: 0305-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Laboratory of Molecular Endocrinology
× corresponding author
# (joint) last author

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