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Title: Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system
Authors: Vankelecom, Hugo ×
Carmeliet, Peter
Van Damme, Jozef
Billiau, Alfons
Denef, Carl #
Issue Date: Jun-1989
Series Title: Neuroendocrinology. vol:49 issue:1 pages:102-6
Abstract: Reaggregate cell cultures of mouse or rat anterior pituitary were found to produce interleukin-6 (IL-6), a cytokine known for its multiple actions in the immune system. Studies on aggregates prepared from differentially enriched pituitary cell populations revealed the presence of folliculo-stellate (FS) cells to be essential for IL-6 production. Aggregates that contained only hormone-secreting, but no FS cells, failed to produce IL-6. Furthermore, the yield of IL-6 increased with increasing proportions of FS cells present in the aggregates. It is suggested that IL-6 participates in the local regulation of the secretory function of the hypophysis and may constitute a link between events in the immune system and those in the endocrine system.
ISSN: 0028-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Molecular and Vascular Biology
Faculty of Medicine - miscellaneous
Laboratory of Molecular Immunology (Rega Institute)
Physiology Section (-)
Laboratory of Tissue Plasticity (-)
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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