Title: Robust benchmark dose determination based on profile score methods
Authors: Claeskens, Gerda ×
Aerts, M
Molenberghs, G
Ryan, L #
Issue Date: Dec-2002
Publisher: Kluwer academic publ
Series Title: Environmental and ecological statistics vol:9 issue:4 pages:357-377
Abstract: We investigate several methods commonly used to obtain a benchmark dose and show that those based on full likelihood or profile likelihood methods might have severe shortcomings. We propose two new profile likelihood-based approaches which overcome these problems. Another contribution is the extension of the benchmark dose determination to non full likelihood models, such as quasi-likelihood, generalized estimating equations, which are widely used in settings such as developmental toxicity where clustered data are encountered. This widening of the scope of application is possible by the use of (robust) score statistics. Benchmark dose methods are applied to a data set from a developmental toxicity study.
ISSN: 1352-8505
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Center for Operations Research and Business Statistics (ORSTAT), Leuven
× corresponding author
# (joint) last author

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