Title: Relationship between [Ca2+] changes in nucleus and cytosol
Authors: Himpens, Bernard ×
De Smedt, Humbert
Casteels, Rik #
Issue Date: Feb-1995
Series Title: Cell calcium. vol:16 issue:4 pages:239-46
Abstract: The free calcium concentration in nucleus ([Ca2+]n) and in cytoplasm ([Ca2+]c) of single cells were estimated by confocal laser microscopy using the Ca(2+)-indicator Indo-1. It is shown that in various cell types a nucleo-cytosolic Ca(2+)-gradient is present at rest and during stimulation. The direction and the extent of the nucleo-cytosolic Ca(2+)-gradient may vary with the cell type, differentiation status, phosphorylation conditions and also with the type of agonist. Evidence is given for the role of extra- and intranuclear storage sites as well as for Ca(2+)-influx. Finally potential artefactual interference with the measurements is discussed.
ISSN: 0143-4160
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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