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Title: Stimulation of prolactin release by angiotensin II in superfused rat anterior pituitary cell aggregates
Authors: Schramme, Carla ×
Denef, Carl #
Issue Date: Sep-1983
Series Title: Neuroendocrinology. vol:36 issue:6 pages:483-5
Abstract: Superfusion of rat anterior pituitary cell aggregates with 10-min pulses of 0.1-10 nM angiotensin II (AII) resulted in a prompt and concentration-dependent rise of PRL release. The effect could be blocked by saralasin, an AII receptor antagonist. The response to AII, but not that to TRH, was rapidly desensitized: a 10 nM AII pulse caused an 80% depression of the response to a subsequent 10 nM pulse given 50 min later. The data provide a possible functional significance for the renin-angiotensin system recently demonstrated in the anterior pituitary.
ISSN: 0028-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
× corresponding author
# (joint) last author

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