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Title: Subconductance states in cardiac sodium channels
Authors: Nilius, Bernd ×
Vereecke, Johan
Carmeliet, Edward #
Issue Date: Sep-1989
Series Title: Biomedica biochimica acta. vol:48 issue:5-6 pages:S354-7
Abstract: Single Na channel currents were studied in cell-attached patches from guinea-pig ventricular myocytes in the presence of DPI 201-106. In addition to openings with a single channel conductance of 15 pS, two other types of events occur that are characterized by a conductance of 5 and 8 pS. The low conductance state is less sensitive to block by TTX than the higher conductance states. The medium conductance state has a reversal potential which is similar to the high conductance channel. It is argued that the low conductance channel is a second type of Na channel, whereas the medium conductance channel appears to be a low conductance substate of the normal Na channels.
ISSN: 0232-766X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Molecular and Cellular Signaling
Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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