Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude-mice
Vanginckel, R Distelmans, W Debrabander, M Callens, M Janssens, B Jagers, E Wouters, Leo Decoster, R Janssen, Paj #
Pergamon-elsevier science ltd
European journal of cancer vol:28A issue:6-7 pages:1137-1139
Fragments of human colorectal adenocarcinomas were inserted under the renal capsule of nude mice. The growth of these tumour grafts was significantly inhibited by the combination of 5-fluorouracil (5-FU) and levamisole. An alternating regimen of levamisole 2.5 mg/kg and 5-FU 20 mg/kg decreased the size of tumour implants by 33-59% and/or increased the number of macroscopically disappeared fragments in the combined group compared with ineffective monotherapy with saline, levamisole or 5-FU. This model could be valuable for investigating the mechanism of action of levamisole and to evaluate the effects of this adjuvant therapy in other oncological settings.