Title: Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude-mice
Authors: Vanginckel, R
Distelmans, W
Debrabander, M
Callens, M
Janssens, B
Jagers, E
Wouters, Leo
Decoster, R
Janssen, Paj #
Issue Date: 1992
Publisher: Pergamon-elsevier science ltd
Series Title: European journal of cancer vol:28A issue:6-7 pages:1137-1139
Abstract: Fragments of human colorectal adenocarcinomas were inserted under the renal capsule of nude mice. The growth of these tumour grafts was significantly inhibited by the combination of 5-fluorouracil (5-FU) and levamisole. An alternating regimen of levamisole 2.5 mg/kg and 5-FU 20 mg/kg decreased the size of tumour implants by 33-59% and/or increased the number of macroscopically disappeared fragments in the combined group compared with ineffective monotherapy with saline, levamisole or 5-FU. This model could be valuable for investigating the mechanism of action of levamisole and to evaluate the effects of this adjuvant therapy in other oncological settings.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Rehabilitation Sciences - miscellaneous
# (joint) last author

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