Title: Differential effects of verapamil and flunarizine on cardiac L-type and T-type Ca channels
Authors: Tytgat, Jan ×
Vereecke, Johan
Carmeliet, Edward #
Issue Date: Jun-1988
Series Title: Naunyn-Schmiedeberg's archives of pharmacology. vol:337 issue:6 pages:690-2
Abstract: Whole cell experiments were used to study whether the L-type and the T-type Ca channel in guinea-pig ventricular myocytes are blocked similarly by verapamil and flunarizine. The L-type current is blocked by 5 mumol/l verapamil and 5 mumol/flunarizine in a use-dependent way, and block can be relieved by hyperpolarizing pulses in a potential-dependent way. The T-type current is not affected by 10 mumol/l verapamil while it is blocked by 10 mumol/l flunarizine in a use-dependent way. Verapamil selectively blocks the L-type channel in contrast to flunarizine.
ISSN: 0028-1298
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
Physiology Section (-)
Laboratory of Molecular and Cellular Signaling
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science