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Title: PMR1/SPCA Ca2+ pumps and the role of the Golgi apparatus as a Ca2+ store
Authors: Wuytack, Frank ×
Raeymaekers, Luc
Missiaen, Ludwig #
Issue Date: May-2003
Series Title: Pflügers Archiv : European journal of physiology. vol:446 issue:2 pages:148-53
Abstract: Besides the well-known sarco/endoplasmic-reticulum Ca(2+)-transport ATPases (SERCA), animal cells contain a much less characterized P-type Ca(2+)-transport ATPase: the PMR1/SPCA Ca(2+)/Mn(2+)-transport ATPase. SPCA is mainly targeted to the Golgi apparatus. Phylogenetic analysis indicates that it might be more closely related to a putative ancestral Ca(2+) pump than SERCA. SPCA supplies the Golgi apparatus, and possibly other more distal compartments of the secretory pathway, with the Ca(2+) and Mn(2+) necessary for the production and processing of secretory proteins. In the lactating mammary gland, SPCA appears to be the primary pump responsible for supplementing the milk with high (60-100 mM) Ca(2+). It could also play a role in detoxification of cells overloaded with Mn(2+). Mutations in the human gene encoding the SPCA pump ( ATP2C1) result in Hailey-Hailey disease, a keratinocyte disorder characterized by incomplete cell adhesion. Recent observations show that the Golgi apparatus can function as a Ca(2+) store, which can be involved in setting up cytosolic Ca(2+) oscillations.
URI: 
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Cellular Transport Systems
Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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