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Title: Action of pinaverium bromide on calmodulin-regulated functions
Authors: Wuytack, Frank ×
De Schutter, G
Casteels, Rik #
Issue Date: Oct-1985
Series Title: European Journal of Pharmacology vol:114 issue:1 pages:85-8
Abstract: Pinaverium bromide at concentrations below 10(-5) M did not inhibit calmodulin-dependent enzymes such as phosphodiesterase and the Ca transport ATPase of the plasma membrane. At higher concentrations the compound interacted with the stimulation of those enzymes by calmodulin and also inhibited the calmodulin-independent activity. A similar inhibitory action was observed for the NaK ATPase. It is concluded that the inhibitory action of pinaverium bromide on smooth muscle concentration at concentrations below 10(-5) M was due to its interaction with the voltage-dependent Ca channels and not to its interference with the calmodulin-dependent activation of the contractile proteins.
URI: 
ISSN: 0014-2999
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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