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Title: Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin
Authors: Carmeliet, Peter ×
Vankelecom, Hugo
Van Damme, Jozef
Billiau, A
Denef, Carl #
Issue Date: 1991
Publisher: Karger
Series Title: Neuroendocrinology. vol:53 issue:1 pages:29-34
Abstract: The release of the immunologically active cytokine interleukin-6 (IL-6) by cultured anterior pituitary cell aggregates was found to increase with the age of the donor rats. The glucocorticoid hormone dexamethasone (DEX) dose-dependently inhibited the release of IL-6, the IC50 being 2.43 +/- 0.93 nM. The sex steroids dihydrotestosterone and estradiol were without detectable effect. The adenylate cyclase activator forskolin increased IL-6 release in aggregate cultures in the presence of DEX. It is concluded that IL-6 release by anterior pituitary cells is subject to developmental changes and under regulatory control of biologically active substances.
ISSN: 0028-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Physiology Section (-)
Molecular and Vascular Biology
Academic Center for General Practice
Faculty of Medicine - miscellaneous
Laboratory of Immunobiology (Rega Institute)
Laboratory of Molecular Immunology (Rega Institute)
Laboratory of Tissue Plasticity (-)
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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