Title: Pharmacology of inositol trisphosphate receptors
Authors: Bultynck, Geert ×
Sienaert, Ilse
Parys, Jan
Callewaert, Geert
De Smedt, Humbert
Boens, Noël
Dehaen, Wim
Missiaen, Ludwig #
Issue Date: Mar-2003
Series Title: Pflügers Archiv : European journal of physiology. vol:445 issue:6 pages:629-42
Abstract: In almost all cells, cytosolic Ca(2+) is a crucial intracellular messenger, regulating many cellular processes. In non-excitable as well as in some excitable cells, Ca(2+) release from the intracellular stores into the cytoplasm is primarily initiated by the second messenger inositol 1,4,5-trisphosphate (IP(3)), which interacts with the IP(3) receptor (IP(3)R), a tetrameric intracellular Ca(2+)-release channel. This review focuses on the pharmacological modulation of the various functionally important sub-domains of the IP(3)R, including the IP(3)-binding domain, calmodulin-binding sites, adenine nucleotide-binding sites and the sites for interaction for FK506-binding proteins and other regulators. We will particularly focus on the pharmacological tools that interfere with these domains and discuss their relative specificity for the IP(3)R, thereby indicating their potential usefulness for unraveling the complex functional regulation of the IP(3)R.
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Molecular Imaging and Photonics
Molecular Design and Synthesis
Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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