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Title: The heat labile phosphatase modulator (inhibitor-2) complex from rabbit skeletal muscle
Authors: Yang, Shiaw-Der ×
Vandenheede, Jackie
Merlevede, Wilfried #
Issue Date: Aug-1983
Series Title: Biochemical and Biophysical Research Communications vol:113 issue:2 pages:439-45
Abstract: The heat stable phosphatase modulator protein (inhibitor-2) has been shown to play a crucial role in the reversible ATP, Mg-dependent activation of a multisubstrate protein phosphatase. The modulator activity is acid and heat stable and resides in a small asymmetrical protein which, after boiling migrates in sucrose density gradient centrifugation with a molecular weight of 17K. The present report shows that in unboiled rabbit skeletal muscle preparations all the modulator activity is found associated with a heat labile protein component, which imposes an important regulatory feature on the heat stable activity. The heat labile complex migrates in sucrose density gradient centrifugation as a Mr = 70K protein.
URI: 
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
× corresponding author
# (joint) last author

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