Title: Blockers of volume-activated Cl- currents inhibit endothelial cell proliferation
Authors: Voets, Thomas ×
Szücs, G
Droogmans, Guillaume
Nilius, Bernd #
Issue Date: Nov-1995
Series Title: Pflügers Archiv : European journal of physiology. vol:431 issue:1 pages:132-4
Abstract: Volume-activated Cl- currents (ICl,vol) and cell growth have been measured in cultured endothelial cells from bovine pulmonary artery (CPAE) in the absence and presence of compounds which block these currents. The anti-oestrogen drug tamoxifen, which efficiently arrests the growth of breast cancer cells (1), inhibits both ICl,vol and cell proliferation with IC50 of 3.8 and 4.8 micromol/l respectively.NPPB and quinine, which also block ICl,vol, inhibit the growth of CPAE cells as well. Current and cell growth were closely correlated under all these conditions.We conclude that ICl,vol might be involved in the control of endothelial cell growth and thus might be important for the modulation of vascularisation and vascular remodelling.
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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