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Title: Translocation (11;14): a cytogenetic anomaly associated with B-cell lymphomas of non-follicle centre cell lineage
Authors: Vandenberghe, E ×
Peeters, Christiane
van den Oord, Joost
Wlodarska, Iwona
Delabie, Jan
Stul, Michel
Thomas, José
Michaux, J L
Mecucci, Christina
Cassiman, Jean-Jacques #
Issue Date: Apr-1991
Series Title: Journal of Pathology vol:163 issue:1 pages:13-8
Abstract: Nine patients with t(11;14) and B non-Hodgkin's lymphomas composed of small to intermediately sized cells with irregular nuclei are described. Immunophenotyping was performed on seven cases, which were M+, D- with light chain restriction, CD5+, CD10-, and CD20+, suggesting that they were non-follicle centre cell lymphomas. The translocation (11;14) (in three cases the only cytogenetic anomaly) was associated with rearrangement of bcl-1 in four of the five cases investigated. Translocation (11;14) has been described in an apparently heterogeneous group of low-grade lymphoid malignancies which we suggest have a non-follicle centre cell lineage in common. This translocation may be associated with these lymphomas in the same way that t(14;18) is associated with follicle centre cell lymphomas.
ISSN: 0022-3417
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Clinical Genetics Section (-)
Human Mutations and Polymorphisms Section (-)
Department of Oncology - miscellaneous
Forensic Biomedical Sciences
Laboratory for Genetics of Malignant Disorders
Clinical Genetics
× corresponding author
# (joint) last author

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