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Title: Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors
Authors: Denys, Hannelore ×
Jadidizadeh, Ali
Amini Nik, Saeid
Van Dam, Kim
Aerts, Stein
Alman, Benjamin A
Cassiman, Jean-Jacques
Tejpar, Sabine #
Issue Date: Jan-2004
Publisher: Scientific & Medical Division, Macmillan Press
Series Title: Oncogene vol:23 issue:3 pages:654-64
Abstract: Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors in which beta-catenin-mediated TCF-3-dependent transcription is activated. To provide more insight into the pathophysiology of these tumors, expression profiles were generated using oligonucleotide arrays (Affymetrix). In total, 69 differentially expressed genes were identified in desmoids compared to normal fibroblasts (fascia) from the same patients. The differential expression of a selection of genes was confirmed using RT-PCR and Northern blotting. We further evaluated the insulin-like growth factor-binding protein 6 (IGFBP-6), a gene that was consistently downregulated in all desmoids tested. Promotor studies and electromobility shift assays revealed two functional beta-catenin/TCF-responsive elements in the human IGFBP-6 promoter. These findings suggest that IGFBP-6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors.
URI: 
ISSN: 0950-9232
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Human Mutations and Polymorphisms Section (-)
Department of Human Genetics - miscellaneous
Translational Research in GastroIntestinal Disorders
Forensic Biomedical Sciences
Molecular Digestive Oncology (+)
× corresponding author
# (joint) last author

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