Title: Nicastrin: gatekeeper of the gamma-secretase complex
Authors: De Strooper, Bart # ×
Issue Date: Aug-2005
Series Title: Cell vol:122 issue:3 pages:318-20
Abstract: The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex. They show that the nicastrin extracellular domain is essential for recognition of substrate by the gamma-secretase.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Status SizeFormat
DeStrooper.pdf Published 73KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science