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Title: A quantitative trait locus on 13q14.2 for trunk strength
Authors: Huygens, Wim ×
Thomis, Martine
Peeters, Maarten
Aerssens, Jeroen
Janssen, Rob G J H
Vlietinck, Robert
Beunen, Gaston #
Issue Date: Dec-2004
Series Title: Twin research : the official journal of the International Society for Twin Studies. vol:7 issue:6 pages:603-606
Abstract: Previous findings show strong evidence for the role of retinoblastoma (Rb) in myoblast proliferation and differentiation. However, it is not known whether variation in the retinoblastoma gene (RB1 ) is responsible for normal variation in human muscle strength. Therefore, a linkage analysis for quantitative traits was performed on 329 young male siblings from 146 families with muscle strength, using a polymorphic marker in RB1 (D13S153 on 13q14.2). Trunk strength, a general strength indicator that requires activation of large muscle groups, was measured on a Cybex TEF isokinetic dynamometer. We found evidence for linkage between locus D13S153 at 13q14.2 and several measurements of trunk flexion with LOD scores between 1.62 and 2.78 (.002< p <.0002). No evidence for linkage was found with trunk extension. This first exploration of the relationship between RB1 and human muscle strength through linkage analysis warrants efforts for further fine mapping of this region.
URI: 
ISSN: 1369-0523
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Exercise Physiology Research Group
Clinical Genetics Section (-)
Department of Kinesiology - miscellaneous
Physical Activity, Sports & Health Research Group
× corresponding author
# (joint) last author

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