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Title: Four cytogenetic subgroups can be identified in endometrial polyps
Authors: Dal Cin, Paola ×
Vanni, R
Marras, S
Moerman, Philippe
Kools, Patrick
Andria, M
Valdes, E
Deprest, Jan
Van de Ven, Willem
Van den Berghe, Herman #
Issue Date: Apr-1995
Series Title: Cancer Research vol:55 issue:7 pages:1565-8
Abstract: We have cytogenetically investigated a total of 33 simple benign endometrial polyps, 7 of which have been reported previously. Clonal chromosome rearrangements are found in 19 of 33 lesions (57%). Three major cytogenetically abnormal subgroups can be distinguished: (a) those with rearrangements in the 6p21-p22 region; (b) those with rearrangements of the 12q13-15 region; (c) those with rearrangements of the 7q22 region. A normal karyotype is found in a fourth subgroup. Recombinations of the 6p21-22 region with 2q35 and 10q22, as well as rearrangements of 7q22, have not been described before. It can be concluded that endometrial polyps, like several other types of benign mesenchymal tumors, present several cytogenetically different subgroups despite a seemingly identical clinical and morphological appearance. It is mandatory, therefore, to look for a common denominator of these tumors at the molecular level.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Basic Research in Gynaecology Section (-)
Clinical Genetics Section (-)
Translational Cell & Tissue Research
Foetal Medicine Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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