Title: Presenilin 1: more than just gamma-secretase
Authors: Raemaekers, Tim ×
Esselens, Carl
Annaert, Wim #
Issue Date: Aug-2005
Publisher: Portland Press
Series Title: Biochemical society transactions vol:33 issue:Pt 4 pages:559-62
Abstract: Presenilin 1 plays a central catalytic role in the gamma-secretase processing of amyloid precursor protein, Notch and many other substrates. However, this core component clearly mediates independently several other physiological roles in the cell/neuron. Besides its involvement in beta-catenin degradation, we discuss here the recent implication of presenilin 1 in the turnover of the intercellular cell adhesion molecule, telencephalin, through a degradation route that bears autophagic characteristics. Activation of the endosomal/lysosomal system in general and autophagic degradation in particular, is finally briefly discussed in the context of neurodegenerative diseases.
ISSN: 0300-5127
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Laboratory of Membrane Trafficking
Biomedical Sciences Group Management - miscellaneous
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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