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Title: Identification of multiple copies of a 20q-chromosome in a case of myelodysplastic syndrome: a FISH study
Authors: Falzetti, D ×
Vermeesch, Joris
Hood, T L
Nacheva, E P
Matteucci, C
Martelli, M F
Van den Berghe, Herman
Marynen, Peter
Mecucci, Christina #
Issue Date: May-1999
Series Title: Leukemia research. vol:23 issue:4 pages:407-13
Abstract: In myelodysplastic syndromes (MDS) karyotypic aberrations identify subgroups of patients with distinct clinical-morphological features and can be relevant in risk assessment of developing leukemia. Often conventional cytogenetic analysis is not sufficiently informative due to the presence of partially or completely unrecognizable chromosome markers. By chromosome microdissection (MD) and fluorescence in situ hybridization (FISH) we investigated the nature of a karyotypic marker occurring in multiple copies in one case of MDS arisen in a patient previously treated for breast cancer. Results showed dicentrics derived from telomeric fusion between interstitially deleted 20q-chromosomes. The abnormal karyotype resulted into polysomy for a deleted chromosome 20q.
ISSN: 0145-2126
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Clinical Genetics Section (-)
Clinical Genetics
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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