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Title: Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: a report of the CHAMP collaborative study group. CHromosomes And MorPhology
Authors: Mandahl, N ×
Akerman, M
Aman, P
Dal Cin, Paola
De Wever, Ivo
Fletcher, C D
Mertens, F
Mitelman, F
Rosai, J
Rydholm, A
Sciot, Raphael
Tallini, G
Van den Berghe, Herman
Van de Ven, Willem
Vanni, R
Willén, H #
Issue Date: Oct-1996
Series Title: International Journal of Cancer vol:67 issue:5 pages:632-635
Abstract: Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-12 aberrations. All 4 tumors with loss of segments from 12q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of 12q material were diagnosed as ALT. One or three extra copies of 12q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.
ISSN: 0020-7136
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Surgical Oncology
Translational Cell & Tissue Research
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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