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Title: A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1
Authors: Höppener, J W ×
De Wit, M J
Simarro-Doorten, A Y
Roijers, J F
van Herrewaarden, H M
Lips, C J
Parente, F
Quincey, D
Gaudray, P
Khodaei, S
Weber, G
Teh, B
Farnebo, F
Larsson, C
Zhang, C X
Calender, A
Pannett, A A
Forbes, S A
Bassett, J H
Thakker, R V
Lemmens, Irma
Van de Ven, Willem
Kas, Koen #
Issue Date: Oct-1998
Series Title: Genomics. vol:50 issue:2 pages:251-9
Abstract: In the process of identification of the multiple endocrine neoplasia type 1 gene, which was recently published, we isolated a novel gene in the 11q13 region. This gene (named ZFPL1, for zinc-finger protein-like 1) is expressed strongly in the exocrine pancreas as a 1.4-kb polyadenylated RNA encoding a putative protein of 310 amino acids. A mouse EST contig predicts an equally sized murine protein with 91% amino acid sequence identity to the human protein. No significant homology with known proteins could be found through database screening. However, zinc-finger-like domains and leucine-zipper-like motifs in the predicted ZFPL1 protein were identified, suggesting the presence of DNA-binding and dimerization domains possibly involved in transcription regulation. This notion is supported by the presence of a putative bipartite nuclear localization signal. This paper presents the full-length cDNA sequence for this gene, its genomic structure and chromosomal orientation, and expression studies by Northern blot hybridization and RNA in situ hybridization.
ISSN: 0888-7543
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Associated Laboratories - miscellaneous (-)
× corresponding author
# (joint) last author

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