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Title: Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
Authors: Tejpar, Sabine ×
Li, C
Yu, C
Poon, R
Denys, Hannelore
Sciot, Raphael
Van Cutsem, Eric
Cassiman, Jean-Jacques
Alman, B A #
Issue Date: Jul-2001
Series Title: British Journal of Cancer vol:85 issue:1 pages:98-101
Abstract: Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.
ISSN: 0007-0920
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Human Mutations and Polymorphisms Section (-)
Translational Research in GastroIntestinal Disorders
Forensic Biomedical Sciences
Molecular Digestive Oncology (+)
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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