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Title: Potential therapeutic use of antibodies directed towards HuIFN-gamma
Authors: Froyen, Guido ×
Billiau, An #
Issue Date: Sep-1997
Series Title: Biotherapy (Dordrecht, Netherlands) vol:10 issue:1 pages:49-57
Abstract: IFN-gamma is an important regulator of immune responses and inflammation. Studies in animal models of inflammation, autoimmunity, cancer, transplant rejection and delayed-type hypersensitivity have indicated that administration of antibodies against IFN-gamma can prevent the occurrence of diseases or alleviate disease manifestations. Therefore, it is speculated that such antibodies may have therapeutical efficacy in human diseases. Since animal-derived antibodies are immunogenic in patients several strategies are being developed in order to reduce or abolish this human anti-mouse antibody (HAMA) response. In our laboratory, we have constructed a single-chain variable fragment (scFv) derived from a mouse antibody with neutralizing potential for human IFN-gamma. A scFv consists of only variable domains tethered together by a flexible linker. The scFv was demonstrated to neutralize the antiviral activity of HuIFN-gamma in vitro and therefore might be considered as a candidate for human therapy.
ISSN: 0921-299X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine - miscellaneous
Molecular Genetics Section (-)
Human Genome Laboratory
Department of Human Genetics - miscellaneous
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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