Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
Author:
Keywords:
Adult, Arthroscopy, Cartilage Diseases, Collagen, Cryopreservation, DNA, Humans, Knee Injuries, Male, Menisci, Tibial, Polymerase Chain Reaction, Transplantation, Homologous, Science & Technology, Life Sciences & Biomedicine, Orthopedics, Sport Sciences, Surgery, meniscus, allograft, meniscal transplantation, DNA analysis, cryopreservation, 1103 Clinical Sciences, 3202 Clinical sciences
Abstract:
SUMMARY: Meniscal transplantation is frequently performed in young patients with a single meniscal-deficient compartment as a result of previous total meniscectomy. Indications, operative techniques, and preservation of meniscal allografts have been studied extensively. In this study we compared the DNA profile of a meniscal allograft with that of the human recipient 1 year after transplantation. Applying techniques routinely used in forensic analysis, we were able to show that the DNA profile of the meniscal allograft was 95% identical to that of the human recipient. These findings indicate that 1 year after transplantation the meniscal allograft is nearly completely repopulated by host cells.