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Title: Genetic abnormalities and male infertility. A comprehensive review
Authors: Thielemans, B F ×
Spiessens, Carl
D'Hooghe, Thomas
Vanderschueren, Dirk
Legius, Eric #
Issue Date: Dec-1998
Publisher: Elsevier
Series Title: European Journal of Obstetrics & Gynecology and Reproductive Biology vol:81 issue:2 pages:217-25
Abstract: The development of assisted reproductive technologies, such as intracytoplasmic sperm injection (ICSI) substantially improved the outlook for patients with severe male fertility problems. However this implies that for the first time genetic defects associated with male in- or subfertility might be transmitted to offspring and result in genetic disease [de Kretser DM, The potential of intracytoplasmic sperm injection (ICSI) to transmit genetic defects causing male infertility. Reprod. Fertil. Dev. 1995;7:137-142]. The knowledge of male specific fertility genes on the Y chromosome increased enormously in the last decade. The SRY gene plays a critical role in gonadal differentiation. DAZ, SPGY and related genes on the Y chromosome are very important for spermatogenesis. Interstitial Y-chromosomal microdeletions encompassing the AZFa, b or c region have become an additional class of genetic abnormalities causing male infertility. A review is given of the different genetic aspects of male infertility.
URI: 
ISSN: 0301-2115
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Clinical Genetics Section (-)
Assisted Reproductive Technology Laboratory (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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