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Title: T-cell lymphoma developing in Hodgkin's disease: evidence for two clones
Authors: Wlodarska, Iwona ×
Delabie, Jan
Peeters, Christiane
Mecucci, Christina
Stul, Michel
Verhoef, Gregor
Cassiman, Jean-Jacques
Van den Berghe, Herman #
Issue Date: 1993
Series Title: Journal of Pathology vol:170 issue:3 pages:239-48
Abstract: A case of peripheral T-cell lymphoma (PTL) occurring in a patient with Hodgkin's disease (HD) in relapse is described. The second neoplasm developed 25 months after the diagnosis of HD. Cytogenetic analysis on the lymph node biopsy at the time of diagnosis of PTL revealed the co-existence of two distinct, abnormal cell clones. The first clone was characterized by a reciprocal translocation t(5;7)(q13;q35) involving 7q35, namely the TCR-beta gene, as expected in T-cell lymphomas. The second cell clone carried trisomies for chromosomes 2, 5, 7, and 14. By immunophenotypic and molecular analysis as well as by in situ hybridization, it was possible to prove that the malignant T-cells and the Reed-Sternberg cells corresponded to different cell clones, one carrying the structural chromosome abnormalities and one carrying the numerical chromosome anomalies. These results indicate that the present case represented a true composite lymphoma.
ISSN: 0022-3417
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Translational Cell & Tissue Research
Hematology Section (-)
Human Mutations and Polymorphisms Section (-)
Forensic Biomedical Sciences
Laboratory for Genetics of Malignant Disorders
Clinical Genetics
× corresponding author
# (joint) last author

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